Genomic alterations are changes that occur within the DNA of cancer cells. Some of these changes accelerate the growth of cancer. Some respond well to specific therapies. With a clear picture of the genomic alterations in your tumor, your doctor may be able to recommend a targeted therapy. In general, targeted therapies have fewer side effects than broad-based chemotherapy. They can also be more selective in stopping the spread of a cancer when other treatments have failed.
Thousands of oncologists, tens of thousands of samples
When should you order Guardant360?
Your patient has advanced cancer and is progressing
Tissue is unobtainable or biopsy yields an insufficient quantity for sequencing
Archived biopsies or results are outdated
One or more interventions have occurred since the last biopsy
Guardant360 is extensively validated
Contraindications for use
Your patient has a hematologic malignancy
Your patient has Stage I or Stage II cancer
Your patient's disease is stable
Your patient is on an active cycle of chemo or radiation therapy
How do we achieve high specificity?
We search for tumor-DNA fragments among billions of cells
We digitally tag each DNA fragment and make millions of copies
Standard sequencing methods introduce errors and false positives
Our digital inference engine reduces these errors by 1000x